Buffalo Bills
| Date | Matchup | Result |
|---|---|---|
| 2025-08-09 | vs  New York Giants | 25-34 L |
| 2025-08-18 | @  Chicago Bears | 38-0 L |
| 2025-08-23 | @  Tampa Bay Buccaneers | 19-23 W |
| 2025-09-08 | vs  Baltimore Ravens | 41-40 W |
| 2025-09-14 | @  New York Jets | 10-30 W |
| 2025-09-19 | vs  Miami Dolphins | 31-21 W |
| 2025-09-28 | vs  New Orleans Saints | 31-19 W |
| 2025-10-06 | vs  New England Patriots | 20-23 L |
| 2025-10-13 | @  Atlanta Falcons | 24-14 L |
| 2025-10-26 | @  Carolina Panthers | 9-40 W |
| 2025-11-02 | vs  Kansas City Chiefs | 28-21 W |
| 2025-11-09 | @ Miami Dolphins | 30-13 L |
| 2025-11-16 | vs Tampa Bay Buccaneers | 44-32 W |
| 2025-11-21 | @  Houston Texans | 23-19 L |
| 2025-11-30 | @  Pittsburgh Steelers | 7-26 W |
| 2025-12-07 | vs  Cincinnati Bengals | 39-34 W |
| 2025-12-14 | @ New England Patriots | 31-35 W |
| 2025-12-21 | @  Cleveland Browns | 20-23 W |
| 2025-12-28 | vs  Philadelphia Eagles | 12-13 L |
| 2026-01-04 | vs New York Jets | 35-8 W |
| 2026-01-11 | @  Jacksonville Jaguars | 24-27 W |
| 2026-01-17 | @  Denver Broncos | 33-30 L |
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