| Max Tomczak | Active | Tomczak signed with the Bills on Thursday. | 2026-06-12 |
| Deven Thompkins | Active | Thompkins signed with the Bills on Thursday. | 2026-06-12 |
| Joshua Palmer | Active | After working off to the side during OTAs, Palmer (ankle) has been back as a participant during mandatory minicamp, Alec White and Maddy Glab of the Bills' offi | 2026-06-11 |
| Cole Bishop | Questionable | Knee | 2026-06-10 |
| Dorian Williams | Questionable | Lower Body | 2026-06-09 |
| Ed Oliver | Active | Oliver (knee) is participating in the Bills' OTAs, Alaina Getzenberg of ESPN.com reports. | 2026-06-03 |
| Mac Dalena | Active | Dalena signed with the Bills on Monday. | 2026-06-01 |
| Demetrius Flannigan-Fowles | Active | Flannigan-Fowles signed a one-year deal with the Bills on Wednesday. | 2026-05-27 |
| Ty Johnson | Active | Johnson (ankle) is participating in OTAs, Jeffrey Barnes of the Bluefield Daily Telegraph reports. | 2026-05-27 |
| James Cook III | Active | Cook was not present for the start of OTAs on Tuesday, Matt Parrino of Syracuse.com reports. | 2026-05-21 |
| DeWayne Carter | Active | Carter (Achilles) participated in Buffalo's OTAs on Wednesday, Matt Parrino of Syracuse.com reports. | 2026-05-20 |
| Terrel Bernard | Active | Bernard (calf) was spotted participating in the Bills' OTAs on Wednesday, Matt Parrino of Syracuse.com reports. | 2026-05-20 |
| Maxwell Hairston | Active | Hairston (ankle) was spotted participating in Buffalo's OTAs on Wednesday, Matt Parrino of Syracuse.com reports. | 2026-05-20 |
| Dalton Kincaid | Active | Kincaid (knee) was a participant in the Bills' OTAs on Tuesday, Sal Capaccio of WGR Sports Radio 550 Buffalo reports. | 2026-05-19 |
| Josh Allen | Active | Coach Joe Brady said Tuesday that Allen is "good to go" after the quarterback underwent foot surgery in the offseason, Sal Capaccio of WGR Sports Radio 550 Buff | 2026-05-19 |
| Keon Coleman | Active | Bills head coach Joe Brady said Tuesday that he advocated for Coleman this offseason and expects him to "be a part of our offense" in 2026, Sal Capaccio of WGR | 2026-05-19 |
| Shane Zylstra | Active | The Bills signed Zylstra to a one-year contract Tuesday. | 2026-05-13 |
| Mike Danna | Active | The Bills signed Danna on Monday. | 2026-05-11 |
| Ja'Mori Maclin | Active | The Bills signed Maclin as an undrafted free agent Friday, Alec White and Maddy Glab of the team's official site report. | 2026-05-08 |
| Ben VanSumeren | Questionable | Knee | 2026-04-29 |
| Tommy Doman Jr. | Active | The Bills selected Doman in the seventh round of the 2026 NFL Draft, 239th overall. | 2026-04-25 |
| Ar'maj Reed-Adams | Active | The Bills selected Reed-Adams in the seventh round of the 2026 NFL Draft, 241st overall. | 2026-04-25 |
| Toriano Pride Jr. | Active | The Bills selected Pride in the seventh round of the 2026 NFL Draft, 220th overall. | 2026-04-25 |
| Zane Durant | Active | The Bills selected Durant in the fifth round of the 2026 NFL Draft, 181st overall. | 2026-04-25 |
| Jalon Kilgore | Active | The Bills selected Kilgore in the fifth round of the 2026 NFL Draft, 167th overall. | 2026-04-25 |
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